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Transferrin, insulin, and leptin are good examples of molecules delivered to the brain through the RME mechanism [69]

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Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement

10.1021/bi100517x 19 ChenW.KoenigsL

This signal alone does not confirm ownership or authenticity of those profiles