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Autoimmune diseases often involve neuroinflammation that can drive migraines, and the anti-inflammatory effects of GLP-1 agonists could be particularly beneficial in this context

As with other complex diseases, the next era likely involves precision, combination therapypairing antiamyloid agents with treatments aimed at metabolic, inflammatory, vascular, and synaptic pathways

Gastroparesis occurs when the muscles of the stomach wall and the nerves that control them stop working correctly

There are multiple strategies aimed at extending the half-life of GLP-1 and enhancing its efficacy (as shown in Figure 1) [1]

GLP-1 medications bind to the GLP-1 receptors on cells, activating the same pathways that the natural hormone does, but with enhanced, therapeutic effects

Because citrulline is not metabolised by arginase in the liver and is efficiently converted to arginine in the kidneys, it may raise plasma arginine levels more effectively than arginine supplementation itself