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MC1R is expressed on keratinocytes, fibroblasts, dendritic cells, mast cells, and other immune cells in the skin , and MT-1-mediated MC1R activation produces anti-inflammatory effects in these cell types through cAMP-mediated suppression of NF-B activation, reduction of pro-inflammatory cytokine production including TNF-alpha and IL-6, inhibition of reactive oxygen species generation, and modulation of dendritic cell maturation and antigen presentation
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Effects of vitamin B12 and folate deficiency on brain development in children
Once activated, these microglia release neurotoxic substances that further damage neuronal synapses and disrupt the synthesis of vital neurotransmitters like acetylcholine, dopamine, and serotonin
