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Yes MTHFR A1298C reduces enzyme activity by approximately 20% in heterozygotes and more in compound heterozygotes (C677T + A1298C)
Chen et al., 2013
The evidence base for use of these drugs, either for off-label indications or as non-approved drugs, is wanting
P., Jr, & Brenner, H
This, in turn, allows fatty-acid producing gut bacteria to thrive at the expense of gut pathogens (Wu et al., 2020) and promotes a normal permeability of the gut-blood barrier (Ramalingam et al., 2010)
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