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Retatrutide's triple mechanismparticularly the addition of glucagon receptor agonismbrings an amplified version of these issues
A recent randomized placebo-controlled trial published by Scirica et al, known as SAVOR-TIMI 53, found no significant difference in ischemic events but did observe higher hospitalizations for heart failure with saxagliptin
For patients with hypertension and diabetes, GLP-1 therapies offer a dual benefit
Peripheral vascular thrombosis has also occurred
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