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Direct cardiac effects of SGLT2 inhibitors
For the in vitro experiments, a murine macrophage cell line RAW 264.7 was used
The authors highlight three urgent priorities: Reframing GLP1 receptor agonists as essential medicines to reduce multimorbidity and premature mortality Addressing inequitable access and affordability, particularly in low and middleincome countries Strengthening healthsystem capacity, alongside prevention and behavioural support, to deliver safe and effective obesity care As the paper makes clear, prevention and treatment are codependent, stigma remains a major barrier, and lessons from HIV show what is possible when access, advocacy and systems change move together.
Instead of injecting a synthetic version of the hormone from the outside, you reprogram cells to manufacture it internally
In the event of an overdose, it is reasonable to employ supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy as dictated by the patient's clinical status
