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This makes it suitable for individuals who do not need appetite control or cannot tolerate GLP-1 agonist side effects

For skin, the primary mechanisms include stimulation of collagen I and III synthesis, increased production of decorin (which organizes collagen fibers), upregulation of VEGF for blood vessel formation, and activation of tissue remodeling through metalloproteinase regulation

An intramuscular B12 shot bypasses gut absorption and typically lasts 2 to 4 weeks

In patients who are deficient, restoring vitamin C can **improve** collagen synthesis and tissue repair, and injections may help when oral absorption is inadequate

Individualized Dosage Adjustment Protocols Every patient reacts differently to vitamin B12 therapy, and dose changes are common