In 2009, EMA approved liraglutide for treatment of type 2 diabetes (T2D), followed by the approval of semaglutide for T2D treatment in 2018
These mechanisms improve glycemia and consistently produce clinically meaningful weight loss (Nauck & Meier, 2020)
It is most potent at the GIP receptor (EC50 of 0.0643 nM), moderately potent at GLP-1 (EC50 of 0.775 nM), and least potent at the glucagon receptor (EC50 of 5.79 nM)
"Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial." The lancet Diabetes & endocrinology 5.4 (2017): 251-260
Altra fonte di acquisto sarebbero alcuni stabilimenti termali, dove il semaglutide (o sue imitazione) verrebbe venduto senza prescrizione medica
Depending on the brand name, you may see semaglutide marketed as either a weight loss or type 2 diabetes drug