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You need steady state to judge whether a dose is adequate

Wester continued, Given that the metabolic syndrome is a major driver of liver-related outcomes both in patients with MASLD and other chronic liver diseases such as alcohol-related liver disease or viral hepatitis C, there could be a similar effect of GLP1 agonists in patients with chronic liver diseases of any etiology with concomitant metabolic traits, such as type 2 diabetes. Using data from the Decoding the Epidemiology of LIVER disease Swedish cohort, researchers aimed to determine the long-term risk for major adverse liver outcomes (MALO) among patients with chronic liver disease and type 2 diabetes who either initiated (n = 1,026) or did not initiate (n = 15,633) GLP1 agonists

As a member of the glutathione peroxidases (GPXs) family, GPX4 utilizes GSH as the electron donor to reduce toxic lipid hydroperoxides (lipid-OOH) in cell membranes to non-toxic lipid alcohols (lipid-OH) and water

Adverse effects related to GLP-1 drugs were an issue, the researchers found

A miscalculation that draws 1 mL instead of 0.1 mL would deliver 2.5 mg in one injection, a 10-fold overdose relative to the starting dose

We also are seeing them used to prevent instet restentinosis and then also pulmonary arterial hypertension, which, as we know, is an area that is desperately in need of other medications. Furthermore, she highlighted the cost-effectiveness of SGLT2 inhibitors, making them a more accessible option for a broader patient population