Indeed, superoxide can undergo dismutation to H 2 O 2 , a mild oxidant that can be converted to the highly reactive hydroxyl radical in the presence of transition metals (Fe 2 + , Cu + ) by means of the Fenton reaction
They may also be an important causative factors in endothelial dysfunction that leads to the development of atherosclerosis, diabetes complications and ischemia perfusion injury [98, 99]
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