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The total impact score for each combination therapy was obtained by summing the individual pathway impact scores, calculated by the Disease Node Impact Score (as described in Section Estimating DM2 DMTs Drug Impact Effect Scores in the DM2-AD comorbidity network) for the pathways modulated by the respective drugs
Current mechanistic and pharmacodynamic understanding of melanocortin-4 receptor activation
Acetyl-L-Carnitine (ALCAR): Includes an acetyl group, allowing it to cross the blood-brain barrier
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