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Demand for these medications, known as GLP-1s, has skyrocketed, but with that demand has come a shadow market: unregulated, compounded versions of GLP-1 drugs being sold online, often with misleading claims about safety and approval

For instance, semaglutide users face a relative risk of 2.10 for constipation compared to placebo, while tirzepatide users have an even higher relative risk of 3.36

Gastrointestinal issues (nausea, vomiting, constipation) can result from the use of both semaglutide and tirzepatide

The pooled estimates may be underestimates of the efficacy of newer agents, although the review could not determine whether stronger weight-loss effects necessarily translate into greater reductions in binge eating

But they dont solve everything

Both ingredients are active, both can cause initial irritation, and using them simultaneously may overwhelm sensitive skin