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Carnitine, derived from an amino acid, is found in nearly all organisms and animal tissue

The study will enroll nearly 5,000 adults with overweight or obesity and it will last about two years

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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)