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Body weight and adiposity models: In diet-induced obesity (DIO) mouse models, retatrutide demonstrated pronounced effects on body weight trajectories over multi-week observation periods compared with vehicle controls
The FDA approved Mounjaro for type 2 diabetes in May 2022 and for chronic weight management (as Zepbound, same molecule) in November 2023
However, probiotics may offer a way to support the gut and alleviate these symptoms, improving tolerance to GLP-1 RAs
A provider may consider phentermine for short-term use in certain patients, particularly when a stimulant-based approach is appropriate, and no cardiovascular contraindications are present
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