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NICE guidelines (NG28) support the use of GLP-1 receptor agonists for type 2 diabetes when glycaemic targets are not achieved with other therapies, and for weight management in specific circumstances (TA875 for Wegovy, TA664 for Saxenda)
A healthy, unstressed cell maintains a vast majority of its glutathione pool in the reduced state, typically sustaining a GSH-to-GSSG ratio of greater than 10:1, and often up to 100:1 in the cytosol
'cause it doesn't matter
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
In addition to being a GLP-1 and GIP receptor agonist, reta, as its coming to be known, activates a hormone called glucagon thats released by pancreatic endocrine cells
This open-label trial (50 patients) aims to optimize dosing and evaluate safety/efficacy of the combo approach, with topline results expected by end of 2024
