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The comparison between the group with normal renal function and the group with severe RI did not demonstrate equivalence (the 95% CI exceeded the no effect limits), and the mean semaglutide exposure was 22% higher in the severe RI group
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10.1016/j.atherosclerosis.2010.04.024 Atherosclerosis 23 CampbellJ
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Clinical Evidence on GLP-1 and Urinary Complications Major randomized controlled trials of semaglutide (SUSTAIN-6, SUSTAIN-7) and tirzepatide (SURPASS trials) did not identify kidney stones as a frequent adverse event
It argues the decision should rest on baseline biomarkers, dietary intake and medication history rather than a blanket protocol
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