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When these proteins are abnormally expressed, the overload cytosolic free ferrous iron leads to intracellular ROS accumulation via the Fenton reaction, which eventually promotes lipid peroxides formation and ferroptosis occurrence (186)

To further explore the clinical application potential of FOXO4-DRI, we conducted liver and kidney function assessments in FOXO4-DRI-treated mice

The first reaction is rate limiting and is catalyzed by the enzyme glutamate-cysteine ligase (GCL, EC 6.3.2.2

Note that the senior author is Wright, the principal investigator of the Harding laboratory

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L., Walzer, C