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As a result, there is an overexpression of p16 and p21 [90]

J Biol Chem 250(22):1670 Zhen Z, Xiaoli L, Tao H, TingFei X, Yufeng Z (2015) Hemolysis and cytotoxicity mechanisms of biodegradable magnesium and its alloys

Contrasting with these actions of GIPR activation to reduce food intake, Gipr knockout (KO) mice, and humans with impaired function GIPR variants, are protected against obesity, also probably through a central effect, as similar observations were made in global KO mice or mice lacking Gipr in nestin, synapsin or VGAT-expressing cells 4,5,9,10,11,12

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