The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)
Mast cell activation may facilitate the entry of pathogenic antibodies into the CNS by disrupting the blood-brain barrier and attracting additional immune cells into neural tissue
GLP1 is an incretin hormone released from the gut after meals
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