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Quick Answer: Most patients experience noticeable appetite suppression within one to two weeks of starting semaglutide, with effects intensifying during dose escalation and peak suppression typically occurring at 16-20 weeks

A patient who has plateaued on semaglutide 2.4 mg or who experienced intolerable side effects on semaglutide may be a candidate for transition to tirzepatide

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When to Talk to Your Healthcare Provider If you are on a GLP-1 medication and experiencing persistent fatigue, muscle loss, poor sleep, constipation that will not resolve, or symptoms that just do not add up, those are signs that something deeper may need attention