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Supplementary Validation Method: LCMS/MS For high-sensitivity detection requirements, liquid chromatographytandem mass spectrometry is used for supplementary validation, especially suitable for trace component analysis and metabolic studies
Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12
For example, concurrent use of chloramphenicol (an antibiotic) may attenuate the hematologic response to vitamin B therapy
This targeted mechanism is central to its role in metabolic research
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