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5-Amino-1MQ works by selectively inhibiting the enzyme Nicotinamide N-methyltransferase (NNMT)
Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study
Study design, and diet and treatment groups are diagrammed in Fig
is essential for mitochondrial energy production, DNA repair, and numerous enzymatic reactions, researchers have investigated how modulation of NNMT activity may influence cellular bioenergetics and metabolic efficiency
Research Summary 5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to obesity and metabolic dysfunction
