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Thats led some health plans to drop coverage or make the obesity treatments more difficult to get

Kaplan LM, Golden A, Jinnett K, et al

This study reports that people who are more interested in GLP-1 medications and more willing to tolerate its negative side effects have higher levels of body dissatisfaction and shame, more bias against fat people, and more disordered eating behaviors

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Theres no strong rationale that a higher dose would have meaningfully slowed cognitive decline

In Phase 3 clinical trials, participants on retatrutide lost up to 28.7% of their body weight in 68 weeks