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Incidence of colorectal cancer Among the seven included studies, three reported the incidence rates of colorectal cancer as outcomes among patients receiving GLP-1 RAs compared to other drugs such as DPP-4 or metformin
Regulatory note: The FDA added injectable GHK-Cu to a high-risk compounded substance list in September 2023
For context, semaglutide (2.4mg) typically achieves about 14.9% weight loss over 68 weeks
Pancreatic DPP-4 As well as influencing glucose homeostasis through its more widespread systemic effects, as discussed above, there is some evidence to suggest that DPP-4 may have local actions in the endocrine pancreas
Our article charts the discovery and development of the long-acting GLP-1 analogs liraglutide and, subsequently, semaglutide
2010;466(7310):S6-7
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