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Funding This work was funded by a Motor Neurone Disease Association grant awarded to RJM (SITraN/Jul16/987-797) and by a tenure track Lectureship awarded to RJM by the Motor Neurone Disease Association funding (SITraN/Apr13/983-797) and the family of Kenneth A Snowman

Reversed-phase HPLC can resolve some misfolded species by their exposed surfaces, so the chromatographic method matters beyond the number it produces

If nausea is persistent and does not respond to dietary adjustments, it may indicate that even the starting dose is too high for your current tolerance

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Ann Czarnik, M.D., FACEP is a board-certified Emergency Medicine physician and Fellow of the American College of Emergency Physicians

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