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In general, most hydrophobic BAs are considered as FXR agonists, while hydrophilic non-12-OH TMCA, UDCA, and T(G)UDCA serve as endogenous FXR antagonists 4,9,10

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In mice, GDF-15 increases satiety and reduces food intake through actions in the central nervous system [99]

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doses over ~1 mg/day are not associated with added benefit

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