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GSTs: glutathione S-transferases
Slow the progression of kidney disease, reduce the risk of kidney failure (end-stage kidney disease), and decrease the likelihood of death due to cardiovascular disease in adults with type 2 diabetes and chronic kidney disease
If tolerance to the satiation effect develops while the dose-limiting nausea does not, the benefitrisk ratio of a given weekly dose would drift over time and a titration schedule built on early-weeks tolerability would be calibrated to the wrong period
It is one of the most widely characterized reference compounds in in-vitro incretin and receptor-signaling research
PMID 10880854
Parents are urged to be cautious
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