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Its main action is reducing the activity of tyrosinase, an enzyme responsible for melanin production
Nature (2009) 462(7269):10812
Vitamin C is water soluble and generally well-absorbed, so while your body can reach a saturation limit if you take too much, it will simply get rid of anything extra
Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome
PMID 4944188
In addition, natural activators of NRF2, such as indole, diterpenes, coumarin and lactone, alleviate renal cell death induced by lipid peroxidation [213]
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