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10.2337/db11-1073 16
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The exact mechanisms behind food noise aren't entirely clear, but if one thing is: food noise can't be reduced to one cause, "but rather a constellation of causes," says Nadler
IGF-1 activates p21 to inhibit UV-induced cell death [PMID: 12642873] Laboratory literature summary: IGF-1 activates p21 to inhibit UV-induced cell death
In this case, it's boosting glucagon, a key blood-sugar-regulating hormone
Clinical trials demonstrated average weight reductions of 15-21% of body weight over 72 weeks in people with obesity (SURMOUNT-1), while more modest weight loss was observed in type 2 diabetes patients (SURPASS trials)
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