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Research by Dalmasso et al
Participants reported better ability to perform daily activities, with the drug reducing physical function limitation scores by over 70% compared to baseline measurements
Topical application works differently from oral supplements
However, these benefits may never come to fruition if GLP-1 RAs induce dietary modifications that create maladaptive gut microbiome shifts, especially over the long term
Rybelsus dosing: Starting dose: 3 mg once daily for 30 days Escalation: 7 mg once daily (can remain here or escalate further) Maximum dose: 14 mg once daily Wegovy (injectable semaglutide for obesity) dosing: Starting dose: 0.25 mg once weekly for 4 weeks Escalation: 0.5 mg, 1.0 mg, 1.7 mg weekly over 16 weeks Maintenance dose: 2.4 mg once weekly The 14 mg daily oral dose delivers steady-state semaglutide exposure equivalent to approximately 0.5 to 1.0 mg weekly subcutaneous dosing, not the 2.4 mg dose proven effective for weight management in the STEP trials (Wilding et al., New England Journal of Medicine, 2021)
These effects typically resolve by weeks three to four as the gut microbiome adapts and the intestinal epithelium adjusts to the compound
