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Clinical perspective SGLT2is and GLP-1RAs exhibit clinical benefits on glycemic control, systolic blood pressure (SBP), body weight, and dyslipidemia, which may all partly contribute to the cardiovascular protection provided by these two drug classes [4, 19]

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297,307 In addition, astrocytes lose AQP4 channels in their endfeet and down-regulate expression of glutamate transporters, thus adding to excitotoxic damage of oligodendrocytes

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