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Among these, the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome plays a significant role in APAP-induced liver injury

However, when these conditions remain unresolved, the UPR switches to proapoptotic and inflammatory pathways with persistent accumulation of misfolded proteins promoting cell death (Chen et al., 2023)

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It has an excellent security profile when administered in suited therapeutic doses [15]

Below this threshold, the anabolic stimulus is subthreshold regardless of overall caloric intake