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10.1186/s12933-017-0564-0 134 SongG.LiuX.LuZ.GuanJ.ChenX.LiY.et al (2025)

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In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea

Lancet 372(25):15021517

FDA prescribing information Zepbound (tirzepatide) Most common adverse reactions for tirzepatide including nausea, diarrhea, constipation, vomiting, abdominal pain, dyspepsia, and injection-site reactions

Staying Informed Its important to stay informed about the medication you are taking