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These medications have sparked tremendous interest, yet its crucial to understand both their benefits and limitations before adding them to your own health journey

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However, nausea is the most commonly reported adverse effect, with incidence varying by medication and dose: approximately 15-30% for most GLP-1 agonists and up to 30-44% at higher doses of semaglutide and tirzepatide according to FDA prescribing information

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Through the PI3K/AKT pathway, GLP-1RAs downregulate mitochondrial BCL2 interacting protein 3 expression, reduce doxorubicin-induced ROS production and -H2AX elevation, and ameliorate doxorubicin-induced cardiotoxicity (171)

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