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10.1007/s10147-011-0361-369 Int

New Research [21] that will be presented at the American Academy of Neurology in April links semaglutide to lower risk of severe migraine pain [21] However, a study in neuromyelitis optica spectrum disorder (NMOSD) found that elevated GLP-1 and GLP-1R levels in cerebrospinal fluid and blood were associated with more severe brain-stem inflammation and acute-phase-reaction-like symptoms (APS)

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Peptide clearance does not scale identically across species, and the animal work used anesthetized preparations and doses far above the human protocol