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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
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Caution is advised when taking ashwagandha and solifenacin together
J Exp Clin Cancer Res 44 , 18 (2025)
As long as a drug is in shortage, it can be made off-label via compound pharmacies
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