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A major mechanism involves the reduction of intracellular drug accumulation through downregulation of solute carrier (SLC) transporters or upregulation of ATP-binding cassette (ABC) transporters, resulting in decreased drug efficacy
However, all observed effects derive from animal models and in vitro research systems
Sci Adv 8:47
Vy bn bit thi im thch hp nht ung creatine cha
So whats the thinking behind replacing the time-honoured treatment of PA by injections with tablets
Some clinics recommend lipotropic injections weekly
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