This is clearly seen when analyzing the metastable states (after MSM clustering) accessible within 1 kcal/mol from the best-bound minima (Supplementary Fig
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172 In conclusion, tackling TME-mediated resistance necessitates integrated therapeutic strategies that dismantle the immunosuppressive, fibrotic, and metabolically reprogrammed tumor niche
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Based on this finding, the research team proposed a new strategy for inhibiting the glutathione metabolic pathway to treat IDH1 mutant glioma