214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound" loading="eager" decoding="async"/>
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Cagrilintide , a long-acting amylin analog, is being studied in combination with semaglutide (the CagriSema combination) with results suggesting up to 25% weight loss potential
![glp 1 reddit bodybuilding M/38/6'1" [283lbs (-)> 214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound](https://i.redd.it/4blytdv5wcrf1.jpeg)
Energy expenditure rises
![glp 1 reddit bodybuilding M/38/6'1" [283lbs (-)> 214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound](https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=10109355687653847)
Consistent sleep and wake times, a cool dark bedroom, limiting alcohol, avoiding caffeine after midday, and managing stress are the most consistently evidence-supported sleep hygiene strategies
![glp 1 reddit bodybuilding M/38/6'1" [283lbs (-)> 214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound](https://i.ytimg.com/vi/JrUn6EP-fbI/sddefault.jpg?v=6a678ae1)
Another study showed 2% alpha-arbutin paired with 10% Trihydroxybenzoic Acid Glucoside and sunscreen faded dark spots and melasma without causing irritation
![glp 1 reddit bodybuilding M/38/6'1" [283lbs (-)> 214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound](https://www.facebeautyscience.com/wp-content/uploads/2024/12/THINNR-BA-2-3.png)
Clinical trials also highlight improvements in blood sugar regulation and cardiovascular health, emphasizing that the benefits extend beyond just weight loss
![glp 1 reddit bodybuilding M/38/6'1" [283lbs (-)> 214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound](https://substackcdn.com/image/fetch/$s_!C3SW!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5cc116fd-71e1-4e61-b476-7827f2d3a048_1194x523.png)
Body composition changes require 3 to 6 months
![glp 1 reddit bodybuilding M/38/6'1" [283lbs (-)> 214lbs => 69] (5months) glp1 med, diet, lots of exercise. : r/progresspics Before and After : r/Zepbound](https://lookaside.instagram.com/seo/google_widget/crawler/?media_id=3947758630219899663)
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