As with BPC-157, the bulk of supportive evidence comes from animal models, knee-specific human data is sparse, and it is not approved for therapeutic use in Australia
The most frequently reported effects include temporary redness at the injection site, mild nausea, lightheadedness, and skin flushing
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In SARS-CoV-2, TMPRSS2 facilitates cellcell fusion in the absence of furin-mediated cleavage at the S1/S2 site, and high TMPRSS2 expression is required to cleave S2 and activate the fusion mechanism for efficient entry 26,27
Literature reports of extracellular activity exist in various species, but genes that direct the enzymes to this compartment remain to be identified