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Blood work considerations As mentioned earlier, creatine will elevate serum creatinine levels
Obstructive Sleep Apnea SURMOUNT-OSA trials investigated GLP2 in adults with moderate-to-severe obstructive sleep apnea and obesity: Significant improvements in apnea-hypopnea index (AHI) from baseline Benefits observed in participants both using and not using positive airway pressure therapy Improvements correlated with weight reduction FDA approval granted in December 2024 for moderate-to-severe OSA treatment Diabetes Prevention Extended follow-up from SURMOUNT-1 assessed diabetes prevention in participants with prediabetes: 94% reduction in progression to type 2 diabetes compared to placebo over 3 years Nearly all participants with prediabetes at baseline converted to normoglycemia Effects diminished during off-treatment follow-up period, indicating ongoing treatment benefit [CALLOUT BOX Highlighted] Important Context: While GLP2 has demonstrated substantial efficacy in multiple large-scale clinical trials, the majority of data comes from industry-sponsored studies with relatively short follow-up periods (40-72 weeks for most trials)
Therefore, you may not see the results youre seeking for the first several months
Weight loss ranges of around 1015% over 612 months , depending on adherence and individual response
At this stage, treatment with oral semaglutide or the comparator was discontinued, and patients were assumed to intensify treatment to basal insulin, with a reduction in HbA1c based on an insulin-nave population derived from the Core multivariate equations estimated by Willis et al
Meanwhile, when dining out, their money is initially skewed towards quick-service restaurants, then subsequently shifts to grocery foodservice (where monthly spending was up by 4.2%), casual dining (+1.5%), and mid-scale restaurants (+9.1%) during the first year
