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Moreover, LC by the reaction with acetyl-CoA and maintaining the acetyl-CoA/CoA ratio in the cell regulates pyruvate dehydrogenase activity [2]

Strohmaier, H

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Abbreviations ACC: Acetyl-CoA Carboxylase ACOX1: Acyl-CoA Oxidase 1 Akt: Protein Kinase B ALT: Alanine Aminotransferase AMP: Adenosine Monophosphate AMPK: AMP-Activated Protein Kinase AST: Aspartate Aminotransferase ATF6: Activating Transcription Factor-6 ATP: Adenosine Triphosphate BMI: Body Mass Index CAT: Catalase CD36: Cluster of Differentiation 36 CHOP: C/EBP Homologous Protein ChREBP: Carbohydrate-Responsive Element-Binding Protein CPT1/CPT1A: Carnitine Palmitoyltransferase-1 CYP450: Cytochrome P450 DHM: Dihydromyricetin DNL: De Novo Lipogenesis ECM: Extracellular Matrix EGCG: Epigallocatechin Gallate eNOS: Endothelial Nitric Oxide Synthase ER: Endoplasmic Reticulum ERS: Endoplasmic Reticulum Stress FAS / FASN: Fatty Acid Synthase FATP5: Fatty Acid Transport Protein-5 FFA: Free Fatty Acids FLD: Fatty Liver Disease FMO5: Flavin-Containing Monooxygenase-5 FXR: Farnesoid X Receptor G6Pase: Glucose-6-Phosphatase GLP-1: Glucagon-Like Peptide-1 GPX: Glutathione Peroxidase GPX4: Glutathione Peroxidase-4 GR: Glutathione Reductase GSH: Reduced Glutathione HDL: High-Density Lipoprotein HO-1: Heme Oxygenase-1 IRS-1: Insulin Receptor Substrate-1 JNK: c-Jun N-terminal Kinase LDL: Low-Density Lipoprotein LPCAT3: Lysophosphatidylcholine Acyltransferase-3 LPS: Lipopolysaccharide LXR: Liver X Receptor Alpha MAFLD: Metabolic-Associated Fatty Liver Disease MAPK: Mitogen-Activated Protein Kinase MASLD: Metabolic DysfunctionAssociated Steatotic Liver Disease MDA: Malondialdehyde mTOR: Mammalian Target of Rapamycin MyD88: Myeloid Differentiation Primary Response-88 NAFLD: Non-Alcoholic Fatty Liver Disease NASH: Non-Alcoholic Steatohepatitis NF-B: Nuclear Factor Kappa-B NQO1: NAD(P)H Quinone Dehydrogenase-1 Nrf2: Nuclear Factor Erythroid-2-Related Factor-2 PEPCK: Phosphoenolpyruvate Carboxykinase PGC-1: Peroxisome Proliferator-Activated Receptor- Coactivator-1 PI3K: Phosphoinositide 3-Kinase PPAR-: Peroxisome Proliferator-Activated Receptor Alpha PTP1B: Protein Tyrosine Phosphatase-1B ROS: Reactive Oxygen Species SIRT1: Sirtuin-1 SOD: Superoxide Dismutase SOD2: Manganese Superoxide Dismutase SREBP-1c: Sterol Regulatory Element-Binding Protein-1c SREBP-2: Sterol Regulatory Element-Binding Protein-2 TG: Triglycerides TGR5: Takeda G-Protein-Coupled Receptor-5 THC: Tetrahydrocurcumin TLR4: Toll-Like Receptor-4 -SMA: Alpha-Smooth Muscle Actin References Amini-Salehi E, Letafatkar N, Norouzi N, Joukar F, Habibi A, Javid M, et al

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