IV administration might be chosen if you are already on IV fluids or need a very rapid correction of vitamin levels
The pivotal Phase 2 trial (NCT04881760), published in The New England Journal of Medicine (Jastreboff et al., 2023), enrolled 338 adults with BMI 30 or higher
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If the mouse figure of 3.5% oral bioavailability holds in humans, 100 mg swallowed delivers roughly 3.5 mg systemically, which is why 100 mg oral and 5 mg subcutaneous end up as the two standard protocols