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Activation of nuclear factor-B (NF-B) induces transcription of target genes that primarily encode survival proteins (e.g., cellular FLICE-like inhibitory protein and inhibitor of apoptosis proteins) via formation of the complex I signalosome after binding to TNF receptor-1
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Together, these findings suggested the importance of GSH modulation during HIV infection, but the pathway involved to alter the GSH levels remained unknown
Fecher C, Trov L, Mller SA, et al