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Luminescence values and enrichment scores were also reasonable predictors of full-length substrate cleavage activity: of the seven substrates that were cleaved, all but one ranked in the top 50th percentile of enrichment scores (Fig
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To assess the importance of lipidation modification to Cagri, pharmacological comparison of Cagri and its non-lipidated backbone (CagriBB) was undertaken using a cAMP response element (CRE)-reporter assay
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