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Other trials The SURMOUNT-5 head-to-head trial (NCT05822830) compared tirzepatide with semaglutide in adults with obesity who did not have type 2 diabetes

PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

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For example, if I have a patient who has a BMI of 42 and multiple comorbidities, I would lean towards Zepbound, since this patient would benefit from losing at least 20% of their body weight

[1] [2] These medications work by mimicking the action of naturally occurring GLP-1 hormone, which stimulates insulin secretion in response to meals, suppresses glucagon release, slows gastric emptying, and promotes satiety