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Unlike phosphonium and aminium-based coupling, this activation strategy is extraordinarily tolerant to elevated temperatures because it avoids the use of excess base, such as DIEA, which leads to epimerization and other problematic side reactions when heated 19
It tells the brain you are full, prompts the pancreas to release insulin, and slows gastric emptying so food moves through the stomach more gradually
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Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression
Am J Case Rep (2011) 12:314
The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: therapeutic targets and treatment
