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ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

The Science of Ageing: Energy Decline vs Oxidative Stress Ageing is an interconnected process, but two of the most significant are declining cellular energy and increasing oxidative stress

Yet, the body's response can vary widely

this was associated with reduced expression of Nrf2

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References Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Prakash A, Tiwari R