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Two independent donor sets of human islets were stimulated with 30 nM tirzepatide (TZP) in the presence of 1M concentrations of exendin(9-39) (Ex9), hGIP(3-30) (GIPR Ant) or the combination

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Functional enrichment analysis was performed with DAVID using the pathways related to metabolism from the KEGG database annotation

Another significant revelation is the complex interaction between host lipid metabolism and microbiome-derived metabolites, adding further intricacy to therapeutic strategies