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Moreover, insulin resistance of the adipose tissue, associated with overweight/obesity, contributes to the flux of FFA from adipose tissue to the liver through unrestricted lipolysis ( de novo lipogenesis, i.e., hepatic FFA synthesis, seems to contribute to lipid deposition ( Figure 2 The gut-derived incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) are responsible for the so-called incretin effect (i.e., the potentiation of glucose-stimulated insulin secretion after meal ingestion) ( Glucagon is a key hormone in the regulation of overall energy homeostasis during the fasting state and other energy-demanding situations
Thyroid 30(4):568579
Patients who care about long-term outcomes also care about supply chain
Some functional-medicine literature discusses a possible link between intestinal permeability, sometimes called leaky gut, and autoimmune thyroid disease, but this remains an area of research rather than settled clinical practice
AGAACG clinical practice guideline on the pharmacological management of chronic idiopathic constipation
PMC 4106761
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